Thrombophilia Profile-Maxi Details in Brief

Thrombophilia Profile Test Overview

The “Thrombophilia Profile-Maxi” is an extensive panel of tests used to evaluate and diagnose various thrombophilic conditions, which are disorders that increase the risk of abnormal blood clot formation (thrombosis). The profile includes a comprehensive set of coagulation and immune-related tests to assess different factors involved in the clotting process and immune responses that can contribute to thrombotic events. The key components of the Thrombophilia Profile-Maxi include:

1. Protein C: Measures the level and activity of Protein C, a natural anticoagulant that helps regulate blood clotting. Low levels of Protein C may increase the risk of clot formation.
2. Protein S: Measures the level and activity of Protein S, another natural anticoagulant protein that assists Protein C in controlling clotting. Deficiencies in Protein S can lead to a prothrombotic state.
3. Antithrombin III (AT-III): Measures the level of AT-III, a critical inhibitor of coagulation factors. Deficiencies in AT-III can result in increased clotting tendencies.
4. Activated Protein C Resistance (APCR): Tests for resistance to activated protein C, which can indicate the presence of a genetic mutation that is associated with an increased risk of clotting.
5. Lupus Anticoagulant: Detects the presence of antibodies that interfere with the normal clotting process, leading to a tendency towards thrombosis.
6. Homocysteine: Measures the level of homocysteine, an amino acid. Elevated homocysteine levels are associated with an increased risk of blood clots.
7. Beta-2 Glycoprotein 1 (IgG / IgM): Detects antibodies against beta-2 glycoprotein 1, which may be linked to autoimmune-related clotting disorders.
8. ACA (Anticardiolipin Antibodies) (IgG / IgM): Detects anticardiolipin antibodies, which are also associated with autoimmune-mediated clotting events.

The Thrombophilia Profile-Maxi is ordered when there is suspicion of an underlying thrombophilia, recurrent blood clots, unexplained thrombotic events, or a family history of thrombosis. It provides a comprehensive assessment of various clotting factors and immune-related markers to aid in the diagnosis and management of thrombophilic conditions. Based on the test results, healthcare providers can devise personalized treatment plans to prevent or manage thrombotic events and reduce the risk of complications.

Reasons for Undergoing the Thrombophilia Profile

The thrombophilia profile is a comprehensive blood test used to assess an individual’s risk of developing abnormal blood clots. It helps identify genetic or acquired conditions that increase the likelihood of thrombosis. This test is often recommended for those with a history of clotting disorders, recurrent thrombosis, or pregnancy-related complications.

Here’s a detailed list of reasons why this crucial diagnostic tool would be recommended by doctors:

• Evaluation of Unexplained Thrombosis: To identify the underlying cause of unexplained or recurrent venous thromboembolism (VTE), especially in young individuals or those without obvious risk factors.
• Family History: If there is a family history of thrombophilia or recurrent thrombotic events, testing can help determine if family members are at risk.
• Recurrent Thrombosis: To investigate the cause of recurrent thrombotic events, which could indicate an underlying thrombophilic condition.
• Unusual Thrombosis Sites: When thrombosis occurs in unusual sites, such as the mesenteric, hepatic, portal, or cerebral veins, thrombophilia testing is warranted.
• Pregnancy Complications: To evaluate women with a history of recurrent miscarriages or other pregnancy complications that may be associated with thrombophilia, particularly antiphospholipid syndrome (APS).
• Risk Assessment and Management: To guide treatment decisions, such as the type and duration of anticoagulation therapy, and to assess the risk of future thrombotic events.

List of Parameters Considered During the Thrombophilia Profile

The thrombophilia profile includes several tests to evaluate different components of the blood’s clotting system:

• Antithrombin (AT): Measures the level of antithrombin, a protein that inhibits the activity of several clotting factors. Low levels indicate a deficiency, which can increase the risk of thrombosis.
• Protein C: Assesses the level of protein C, another anticoagulant protein. Low levels suggest a deficiency, which increases the risk of venous thrombosis.
• Protein S: Evaluates the level of protein S, which works with protein C to inhibit clotting factors. Low levels indicate a deficiency, increasing the risk of venous thrombosis.
• Lupus Anticoagulant: Tests for the presence of lupus anticoagulant, an antibody associated with antiphospholipid syndrome (APS), which is linked to an increased risk of both venous and arterial thrombosis.
• Anticardiolipin Antibodies (ACA): Measures the levels of IgG and IgM anticardiolipin antibodies, also associated with APS and an increased risk of thrombosis.
• Activated Protein C Resistance (APCR) and Factor V Leiden: Tests for resistance to activated protein C and the presence of the factor V Leiden mutation, a common inherited thrombophilia.Anti Beta-2-Glycoprotein-1 Antibodies: Tests for the presence of anti-beta-2-glycoprotein-1 IgG and IgM antibodies, also linked to APS and an increased risk of thrombosis.
• Prothrombin Gene Mutation (G20210A): Tests for the prothrombin gene mutation, another inherited thrombophilia that increases the production of prothrombin, a clotting factor, leading to an increased risk of venous thrombosis.

Home Collection for Thrombophilia Profile Near You

Metropolis Healthcare offers a convenient home collection service for the thrombophilia profile test, making diabetes management easier without compromising on quality. A trained phlebotomist will visit your home to collect a sample, focusing on your comfort and safety while following strict sample handling guidelines. You can expect prompt and accurate results, enabling you to take proactive steps in managing your health. With Metropolis Healthcare’s commitment to accessible and high-quality diagnostic solutions, you can trust us for your thrombophilia profile testing needs from the comfort of your home. Experience a seamless testing process with Metropolis Healthcare’s home collection service and know your thrombotic risk factors.